Restriction of memory B cell differentiation at the germinal center B cell positive selection stage | Zendy

Amparo Toboso-Navasa | Zendy; Arief Gunawan | Zendy; Giulia Morlino | Zendy; Rinako Nakagawa | Zendy; Andrea Taddei | Zendy; Djamil Damry | Zendy; Yash Patel | Zendy; Probir Chakravarty | Zendy; Martin Janz | Zendy; George Kassiotis | Zendy; Robert Brink | Zendy; Martin Eilers | Zendy; Dinis Pedro Calado | Zendy

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Restriction of memory B cell differentiation at the germinal center B cell positive selection stage

Author(s) -

Amparo Toboso-Navasa,

Arief Gunawan,

Giulia Morlino,

Rinako Nakagawa,

Andrea Taddei,

Djamil Damry,

Yash Patel,

Probir Chakravarty,

Martin Janz,

George Kassiotis,

Robert Brink,

Martin Eilers,

Dinis Pedro Calado

Publication year - 2020

Publication title -

the journal of experimental medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.483

H-Index - 448

eISSN - 1540-9538

pISSN - 0022-1007

DOI - 10.1084/jem.20191933

Subject(s) - germinal center , cell , biology , microbiology and biotechnology , b cell , repressor , cell cycle , memory b cell , cellular differentiation , transcription factor , gene , chemistry , immunology , genetics , antibody

Germinal center (GC) positively selected B cells are primarily fated for GC expansion and plasma cell formation. This study reveals that memory B cell differentiation is restricted in positively selected B cells by the MYC–MIZ1 transcriptional repressor complex.

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