KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3 | Zendy

Maho Nagasawa | Zendy; Balthasar A. Heesters | Zendy; Chantal M. A. Kradolfer | Zendy; Lisette Krabbendam | Zendy; Itziar Martínez-González | Zendy; Marjolein J. W. de Bruijn | Zendy; Korneliusz Golebski | Zendy; Rudi W. Hendriks | Zendy; Ralph Stadhouders | Zendy; Hergen Spits | Zendy; Suzanne M. Bal | Zendy

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KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3

Author(s) -

Maho Nagasawa,

Balthasar A. Heesters,

Chantal M. A. Kradolfer,

Lisette Krabbendam,

Itziar Martínez-González,

Marjolein J. W. de Bruijn,

Korneliusz Golebski,

Rudi W. Hendriks,

Ralph Stadhouders,

Hergen Spits,

Suzanne M. Bal

Publication year - 2019

Publication title -

the journal of experimental medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.483

H-Index - 448

eISSN - 1540-9538

pISSN - 0022-1007

DOI - 10.1084/jem.20190490

Subject(s) - innate lymphoid cell , interleukin 7 receptor , cd117 , biology , phenotype , computational biology , microbiology and biotechnology , immunology , immune system , stem cell , genetics , gene , t cell , immunity , il 2 receptor , cd34

The human CD117 + CRTH2 − ILC population contains ILC precursors. Nagasawa et al. segregate this population by the mutually exclusive expression of KLRG1 and NKp46. KLRG1 + ILCs are biased toward the ILC2 lineage, whereas NKp46 clearly defines ILC3-lineage–biased cells.

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