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The human CD117 +  CRTH2 −  ILC population contains ILC precursors. Nagasawa et al. segregate this population by the mutually exclusive expression of KLRG1 and NKp46. KLRG1 +  ILCs are biased toward the ILC2 lineage, whereas NKp46 clearly defines ILC3-lineage–biased cells.

KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3