The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes | Zendy

Danika L. Hill | Zendy; Wim Pierson | Zendy; Daniel J. Bolland | Zendy; Catherine Mkindi | Zendy; Edward J Carr | Zendy; Jiong Wang | Zendy; Sophie Houard | Zendy; Steven W. Wingett | Zendy; R Audran | Zendy; Elizabeth Wallin | Zendy; Said Jongo | Zendy; Kassim Kamaka | Zendy; Martin S. Zand | Zendy; François Spertini | Zendy; Claudia Daubenberger | Zendy; Anne E. Corcoran | Zendy; Michelle A. Linterman | Zendy

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The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

Author(s) -

Danika L. Hill,

Wim Pierson,

Daniel J. Bolland,

Catherine Mkindi,

Edward J Carr,

Jiong Wang,

Sophie Houard,

Steven W. Wingett,

R Audran,

Elizabeth Wallin,

Said Jongo,

Kassim Kamaka,

Martin S. Zand,

François Spertini,

Claudia Daubenberger,

Anne E. Corcoran,

Michelle A. Linterman

Publication year - 2019

Publication title -

the journal of experimental medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.483

H-Index - 448

eISSN - 1540-9538

pISSN - 0022-1007

DOI - 10.1084/jem.20190301

Subject(s) - adjuvant , immunology , t cell receptor , biology , t cell , microbiology and biotechnology , immune system

A rational strategy to achieve optimal vaccine responses is to potentiate Tfh cells and the germinal center response. This work shows the adjuvant GLA-SE enhances circulating Tfh cells and enduring antibody responses to a malaria vaccine in Tanzanian adults.

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