Open AccessCell death–mediated cytokine release and its therapeutic implications
Author(s) -
David E. Place,
ThirumalaDevi Kanneganti
Publication year - 2019
Publication title -
the journal of experimental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.483
H-Index - 448
eISSN - 1540-9538
pISSN - 0022-1007
DOI - 10.1084/jem.20181892
Subject(s) - necroptosis , pyroptosis , programmed cell death , immune system , apoptosis , biology , microbiology and biotechnology , crosstalk , lytic cycle , immunology , biochemistry , virus , physics , optics
Place and Kanneganti review the role of pyroptosis and necroptosis in driving inflammatory diseases, current cytokine blockade therapies, and the potential benefits of targeting the executioners of lytic cell death.
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