A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection | Zendy

Franck J. Barrat | Zendy; Lishan Su | Zendy

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A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection

Author(s) -

Franck J. Barrat,

Lishan Su

Publication year - 2019

Publication title -

the journal of experimental medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.483

H-Index - 448

eISSN - 1540-9538

pISSN - 0022-1007

DOI - 10.1084/jem.20181359

Subject(s) - tlr7 , immunology , tlr9 , autoimmunity , context (archaeology) , biology , interferon type i , interferon , plasmacytoid dendritic cell , immune system , dendritic cell , virology , toll like receptor , innate immune system , genetics , gene , gene expression , paleontology , dna methylation

Following the discovery of plasmacytoid dendritic cells (pDCs) and of their extraordinary ability to produce type I IFNs (IFN-I) in response to TLR7 and TLR9 stimulation, it is assumed that their main function is to participate in the antiviral response. There is increasing evidence suggesting that pDCs and/or IFN-I can also have a detrimental role in a number of inflammatory and autoimmune diseases, in the context of chronic viral infections and in cancers. Whether these cells should be targeted in patients and how much of their biology is connected to IFN-I production remains unclear and is discussed here.

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