NEPHROTOXIC SERUM NEPHRITIS IN RATS | Zendy

Howard C. Goodman | Zendy; James H. Baxter | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

NEPHROTOXIC SERUM NEPHRITIS IN RATS

Author(s) -

Howard C. Goodman,

James H. Baxter

Publication year - 1956

Publication title -

the journal of experimental medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.483

H-Index - 448

eISSN - 1540-9538

pISSN - 0022-1007

DOI - 10.1084/jem.104.4.487

Subject(s) - nephrotoxicity , antigen , kidney , nephritis , antibody , digestion (alchemy) , chemistry , biochemistry , ammonium sulfate , biology , microbiology and biotechnology , endocrinology , immunology , chromatography

A soluble protective factor, capable of absorbing nephrotoxic antibodies from anti-rat kidney serum, can be obtained in high concentration by tryptic digestion of rat kidney homogenate. The factor is no longer antigenic or at most only slightly so. It is stable at 60°, destroyed by boiling, is non-dialyzable, can be precipitated by ammonium sulfate, but resists destruction by proteolytic and other enzymes. In accord with previous studies on the organ localization of the rat tissue antigen responsible for the production of nephrotoxic antibodies, the soluble protective factor, or antigen derivative, can be obtained by tryptic digestion of rat lung, skeletal muscle, heart, and liver.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research