Pursuing the middleman | Zendy

Kendall Powell | Zendy

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Pursuing the middleman

Author(s) -

Kendall Powell

Publication year - 2005

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb1714fta1

Subject(s) - fibronectin , biology , holy grail , extracellular matrix , microbiology and biotechnology , transmembrane protein , memoir , receptor , genetics , art history , world wide web , computer science , art

By the mid-1970s, the idea of a transmembrane molecule linking the cytoskeleton to the extracellular matrix (ECM) had some supporting evidence. Adhesion molecules were hot in areas ranging from developmental biology to tumor biology, and the mounting suggestive evidence that a “fibronectin receptor” existed made it a “Holy Grail” for the next decade, recalls Richard Hynes, discoverer of fibronectin, in a memoir (Hynes, 2004).

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