Open AccessParsing p53 activity
Author(s) -
Rabiya S. Tuma
Publication year - 2004
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb1643rr4
Subject(s) - biology , apoptosis , cell cycle , dna damage , cancer research , cell cycle checkpoint , programmed cell death , microbiology and biotechnology , dna , genetics
Vvertebrate p53 has many talents, including the ability to induce apoptosis and cell cycle arrest in response to DNA damage. At least one of these talents seems to be crucial for suppressing tumor formation, as mice that lack p53 develop early onset T-cell lymphomas and usually die young. New results from Geng Liu, Guillermina Lozano, and colleagues (M.D. Anderson Cancer Center, Houston, Texas) suggest that, for tumor initiation, delay trumps death.
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