Open AccessKrox-20 conducts the Schwann song
Author(s) -
Alan W. Dove
Publication year - 2004
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb1643iti2
Subject(s) - biology , schwann cell , microbiology and biotechnology , myelin , regulator , myelin sheath , transcription factor , neuroscience , genetics , central nervous system , gene
When Schwann cells begin to myelinate large-diameter axons, they stop dividing, become resistant to apoptosis, and start producing myelin proteins. How are all of these changes coordinated? On page 385, Parkinson et al. identify several new signaling interactions in Schwann cells, and show that the transcription factor Krox-20 is a master regulator of myelination.
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