Open AccessShared amyloid oligomer structure proves toxic
Author(s) -
Rabiya S. Tuma
Publication year - 2003
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb1613rr2
Subject(s) - oligomer , biology , antibody , fibril , amyloid (mycology) , toxicity , amyloid fibril , biochemistry , biophysics , microbiology and biotechnology , amyloid β , immunology , chemistry , disease , pathology , medicine , botany , organic chemistry
![Graphic][1] Preincubation of the antibody with oligomers (open bars) protected cells, whereas absence of antibodies and control antibodies had no effect.Kayed/AAAS It was previously thought that the toxicity of Aβ and other amyloids resulted from large insoluble fibrils, but
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