Open AccessRejection and killing, without MPR
Author(s) -
Alan W. Dove
Publication year - 2003
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb1602iti4
Subject(s) - granzyme , biology , granzyme b , proteases , cytotoxic t cell , granzyme a , microbiology and biotechnology , immunology , perforin , biochemistry , in vitro , enzyme
![Graphic][1] Cells lacking MPR still take up granzyme B.Whether destroying a tumor or rejecting a transplanted organ, cytotoxic lymphocytes rely on proteases called granzymes to kill target cells, so the finding two years ago that the action of a granzyme requires the mannose-6-
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