Repressing differentiation | Zendy

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Repressing differentiation

Author(s) -

William Wells

Publication year - 2002

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb1593rr2

Subject(s) - biology , computational biology , microbiology and biotechnology

ain Cheeseman, Georjana Barnes (University of California, Berkeley, CA), and colleagues have peered into a 28-protein mix and found the individual residues responsible for attaching and detaching chromosomes and microtubules. The phosphorylation of these residues by Ipl1p (an Aurora kinase) apparently allows budding yeast cells to convert monopolar chromosome spindle attachments to bipolar attachments. The group used the mass spectrometry (MS) expertise of Scott Anderson and John Yates (Scripps Research Institute, La Jolla, CA) to identify 28 yeast kinetochore proteins (including 5 I

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