Open AccessBig proteins Ran into import difficulties
Author(s) -
Nicole LeBrasseur
Publication year - 2002
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb1591iti3
Subject(s) - ran , biology , gtp' , nuclear transport , importin , gtp binding protein regulators , cell nucleus , nucleus , microbiology and biotechnology , computational biology , g protein , biochemistry , signal transduction , enzyme
![Graphic][1] Large cargo is not imported into the nucleus without GTP (bottom). The need for Ran and GTP in nuclear import reactions depends on the size of the imported cargo, according to new results by Lyman et al. ([page 55][2]), who show that large proteins in particular are
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