Open AccessSlow and steady moves the cell
Author(s) -
Nicole LeBrasseur
Publication year - 2002
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb1576rr2
Subject(s) - counterintuitive , biology , actin , microbiology and biotechnology , pseudopodia , cell , biophysics , genetics , physics , quantum mechanics
More actin-based protrusion should mean more cell movement, or so it has been thought. Yet depletion of the Ena/VASP family of actin-binding proteins, which promote lamellipodial protrusion rates, actually causes cells to move faster. New results from James Bear, Tatyana Svitkina, Frank Gertler (MIT, Cambridge, MA), and colleagues explain this counterintuitive effect by putting the emphasis on the quality rather than the quantity of protrusions.
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