Open AccessA Prion in yeast Huntington's disease
Author(s) -
Alan W. Dove
Publication year - 2002
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb1576iti4
Subject(s) - huntingtin , biology , neurodegeneration , yeast , huntington's disease , huntingtin protein , disease , saccharomyces cerevisiae , genetics , simplicity , fungal prion , computational biology , gene , medicine , philosophy , epistemology , pathology , mutant
![Graphic][1] Huntingtin-like proteins make yeast sick (bottom).Meriin et al., reporting on [page 997][2], have developed the first yeast model for studying Huntington's disease. Yeast cannot undergo neurodegeneration, of course, but the simplicity and genetic manipulability of the
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