Open AccessStop That Cell
Author(s) -
William A. Wells
Publication year - 2002
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb1574mr
Subject(s) - biology , retinoblastoma , suppressor , human disease , retinoblastoma protein , cancer research , cell , genetics , cell cycle , cancer , gene
As a model for human disease, mice lacking a copy of the Rb tumor suppressor are a distinct failure. For starters, they don't get retinoblastoma. Even patches of eye cells that lack both copies of Rb don't become tumors.Tyler Jacks (Massachusetts Institute of Technology, Cambridge, MA) wondered if
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