Open AccessA CONSIDERATION OF THE PERMEABILITY OF CARTILAGE TO INORGANIC SULFATE
Author(s) -
Robert D. Campo,
Dominic D. Dziewiatkowski
Publication year - 1961
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb.9.2.401
Subject(s) - sulfate , chondroitin sulfate , cartilage , in vivo , in vitro , biochemistry , materials science , biology , biophysics , glycosaminoglycan , anatomy , microbiology and biotechnology , metallurgy
On the basis of an examination of autoradiograms of knee-joints fixed so as to remove chondroitin sulfate or inorganic sulfate, or to minimize the loss of both, it is suggested that the cartilage is permeable to inorganic sulfate in vivo and in vitro. In vivo and in vitro, almost as rapidly as it enters the cartilage, inorganic sulfate is utilized by the cells in the synthesis of chondroitin sulfate. The net result is a continuing low concentration of inorganic sulfate in the cartilage.
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