LIPOPROTEIN GRANULES IN THE CORTICAL COLLECTING TUBULES OF MOUSE KIDNEY | Zendy

Fritz Miller | Zendy

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LIPOPROTEIN GRANULES IN THE CORTICAL COLLECTING TUBULES OF MOUSE KIDNEY

Author(s) -

Fritz Miller

Publication year - 1961

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.9.1.157

Subject(s) - biology , osmium , vacuole , membrane , kidney , fixation (population genetics) , biophysics , anatomy , rod , ultrastructure , microbiology and biotechnology , biochemistry , cytoplasm , pathology , endocrinology , medicine , alternative medicine , ruthenium , gene , catalysis

The light and, to a lesser extent, the dark cells of the cortical collecting tubules in mouse kidney contain a great number of granules which according to histochemical tests are composed of phospholipids and proteins. These granules are bounded by a triple-layered membrane measuring approximately 75 A across, and contain one or several crystals with a hexagonal or square lattice. These crystals are built up of rod-shaped units, which appear dense after osmium fixation, measure about 48 A in diameter, and are separated by a light interspace of similar dimensions. The mean center-to-center distance of the rods is about 96 A. The structure is explained as a lipoprotein crystallized within a membrane-bounded vacuole. No relationship between these granules and mitochondria was found. The physiological significance of the granules remains unknown.

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