Electron Microscope Study of the Human Neuromuscular Junction | Zendy

Étienne de Harven | Zendy; Christian Coërs | Zendy

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Electron Microscope Study of the Human Neuromuscular Junction

Author(s) -

Étienne de Harven,

Christian Coërs

Publication year - 1959

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.6.1.7

Subject(s) - osmium tetroxide , synaptic vesicle , basement membrane , electron microscope , endoplasmic reticulum , biology , neuromuscular junction , biophysics , vesicle , anatomy , sarcoplasm , membrane , neuroscience , microbiology and biotechnology , biochemistry , physics , optics

A preliminary electron microscope study of human neuromuscular junction is presented. The biopsy material was taken from the palmarus longus, and fixed routinely in osmium tetroxide and embedded in methacrylate. The structure of the motor endings and the relationship of the synaptic vesicles to the axolemmal membrane are described. The synaptic clefts are filled with an homogeneous material in continuity with the basement membrane covering the muscle fiber. The subneural apparatus is described, and special attention is paid to a vesicular component present in the sarcoplasm of the junctional area, which differs from synaptic vesicles and is presumed to be a derivate of the sarcoplasmic reticulum.

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