Staining of Tissue Sections for Electron Microscopy with Heavy Metals | Zendy

Michael L. Watson | Zendy

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Staining of Tissue Sections for Electron Microscopy with Heavy Metals

Author(s) -

Michael L. Watson

Publication year - 1958

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.4.4.475

Subject(s) - electron microscope , biology , staining , negative stain , microscopy , biophysics , heavy metals , metal , pathology , materials science , optics , chemistry , environmental chemistry , genetics , medicine , physics , metallurgy

Heavy metals may be incorporated from solution into tissue sections for electron microscopy. The resulting increase in density of the tissue provides greatly enhanced contrast with minimal distortion. Relative densities of various structures are found to depend on the heavy metal ions present and on the conditions of staining. Certain hitherto unobserved details are revealed and some sort of specificity exists, although the factors involved are not yet understood.

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