MUCOPOLYSACCHARIDES PRODUCED IN TISSUE CULTURE | Zendy

H. Grossfeld | Zendy; Karl Meyer | Zendy; Gabriel C. Godman | Zendy; Alfred Linker | Zendy

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MUCOPOLYSACCHARIDES PRODUCED IN TISSUE CULTURE

Author(s) -

H. Grossfeld,

Karl Meyer,

Gabriel C. Godman,

Alfred Linker

Publication year - 1957

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.3.3.391

Subject(s) - glycosaminoglycan , hyaluronic acid , chondroitin sulfate , chondroitin , tissue culture , biology , fetus , biochemistry , cell culture , heparan sulfate , sulfation , anatomy , in vitro , pregnancy , genetics

1. A method of mass tissue culture has been devised by which, in a relatively short period of time, samples large enough for chemical isolation of mucopolysaccharides can be obtained. 2. Chemical isolation of acid mucopolysaccharides from mass cultures of human fetal skin, human fetal bone, bovine fetal skin, and rat subcutaneous tissue has been carried out. It has been found that the fibroblasts of each of these tissues produce in tissue culture more than one mucopolysaccharide, namely, hyaluronic acid, and a chondroitin sulfate. 3. The chondroitin sulfate produced by fibroblasts of the above tissues in tissue culture was not fully sulfated. The possible significance of this finding is discussed.

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