Open AccessCDK5 opens the way for DLC1
Author(s) -
Ben Short
Publication year - 2014
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb.2075iti2
Subject(s) - biology , colocalization , microbiology and biotechnology , kinase , focal adhesion , cyclin dependent kinase 5 , phosphorylation , protein kinase a , mitogen activated protein kinase kinase
![Figure][1] DLC1 (red) and CDK5 (green) colocalize (white) at the focal adhesions of non-small cell lung cancer cells.Tripathi et al. describe how the kinase CDK5 promotes the activity and correct localization of the tumor suppressor DLC1.DLC1 is down-regulated in a wide variety of
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