Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms | Zendy

Breane Budaitis | Zendy; Shashank Jariwala | Zendy; Lu Rao | Zendy; Yang Yue | Zendy; David Sept | Zendy; Kristen J. Verhey | Zendy; Arne Gennerich | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms

Author(s) -

Breane Budaitis,

Shashank Jariwala,

Lu Rao,

Yang Yue,

David Sept,

Kristen J. Verhey,

Arne Gennerich

Publication year - 2021

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.202004227

Subject(s) - kinesin , allosteric regulation , molecular motor , motor protein , optical tweezers , docking (animal) , microtubule , biology , biophysics , microbiology and biotechnology , physics , genetics , medicine , receptor , quantum mechanics , nursing

Kinesin-3 motors are fast and superprocessive, but their force generation properties remain unclear. The authors show that KIF1A detaches under low opposing forces but rapidly reattaches to continue motility. Rapid reattachment depends on the class-specific K-loop, whereas mutations linked to neurodevelopmental disorders impair force generation and motility.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research