Open AccessmTORC1 activity is supported by spatial association with focal adhesions
Author(s) -
Yoana Rabanal-Ruíz,
Adam Byron,
Alexander Wirth,
Ralitsa R. Madsen,
Lucia Sedlackova,
Graeme Hewitt,
Glyn Nelson,
Julian Stingele,
Jimi Wills,
Tong Zhang,
André Zeug,
Reinhard Fässler,
Bart Vanhaesebroeck,
Oliver D.K. Maddocks,
Evgeni Ponimaskin,
Bernadette Carroll,
Viktor I. Korolchuk
Publication year - 2021
Publication title -
the journal of cell biology/the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb.202004010
Subject(s) - mtorc1 , microbiology and biotechnology , lysosome , intracellular , biology , cell growth , signal transduction , biochemistry , pi3k/akt/mtor pathway , enzyme
Rabanal-Ruiz and Byron et al. present a novel mechanism of nutrient signaling that identifies FAs as key cellular hubs that coordinate growth factor signaling and amino acid input into the cell and are required for efficient downstream activation of mTORC1.