mTORC1 activity is supported by spatial association with focal adhesions | Zendy

Yoana RabanalRuiz | Zendy; Adam Byron | Zendy; Alexander Wirth | Zendy; Ralitsa R. Madsen | Zendy; Lucia Sedlackova | Zendy; Graeme Hewitt | Zendy; Glyn Nelson | Zendy; Julian Stingele | Zendy; Jimi Wills | Zendy; Tong Zhang | Zendy; André Zeug | Zendy; Reinhard Fässler | Zendy; Bart Vanhaesebroeck | Zendy; Oliver D.K. Maddocks | Zendy; Evgeni Ponimaskin | Zendy; Bernadette Carroll | Zendy; Viktor I. Korolchuk | Zendy

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mTORC1 activity is supported by spatial association with focal adhesions

Author(s) -

Yoana RabanalRuiz,

Adam Byron,

Alexander Wirth,

Ralitsa R. Madsen,

Lucia Sedlackova,

Graeme Hewitt,

Glyn Nelson,

Julian Stingele,

Jimi Wills,

Tong Zhang,

André Zeug,

Reinhard Fässler,

Bart Vanhaesebroeck,

Oliver D.K. Maddocks,

Evgeni Ponimaskin,

Bernadette Carroll,

Viktor I. Korolchuk

Publication year - 2021

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.202004010

Subject(s) - mtorc1 , microbiology and biotechnology , lysosome , intracellular , biology , cell growth , signal transduction , biochemistry , pi3k/akt/mtor pathway , enzyme

Rabanal-Ruiz and Byron et al. present a novel mechanism of nutrient signaling that identifies FAs as key cellular hubs that coordinate growth factor signaling and amino acid input into the cell and are required for efficient downstream activation of mTORC1.

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