Rac1-PAK1 regulation of Rab11 cycling promotes junction destabilization | Zendy

Jennifer C. Erasmus | Zendy; Kasia Smolarczyk | Zendy; Helena Brezovjakova | Zendy; Noor Faizah MohdNaim | Zendy; Encarnación Lozano | Zendy; Karl Matter | Zendy; Vania Braga | Zendy

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Rac1-PAK1 regulation of Rab11 cycling promotes junction destabilization

Author(s) -

Jennifer C. Erasmus,

Kasia Smolarczyk,

Helena Brezovjakova,

Noor Faizah MohdNaim,

Encarnación Lozano,

Karl Matter,

Vania Braga

Publication year - 2021

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.202002114

Subject(s) - rab , pak1 , microbiology and biotechnology , rac1 , biology , gtpase , internalization , exocytosis , phosphorylation , cadherin , membrane , biochemistry , signal transduction , cell

Rac1 promotes malignancy. Oncogenic Rac1 and its effector PAK1 disrupt junctions via internalization of cadherin adhesion receptors by bulk fluid uptake. PAK1 phosphorylates a key regulator of intracellular trafficking, RabGDIβ, thereby modulating its affinity with specific partners (i.e., Rab11) to re-route cadherin away from cell–cell contacts.

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