Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint | Zendy

Mark Jackman | Zendy; Chiara Marcozzi | Zendy; Martina Barbiero | Zendy; Mercedes Pardo | Zendy; Lu Yu | Zendy; Adam L. Tyson | Zendy; Jyoti S. Choudhary | Zendy; Jonathon Pines | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint

Author(s) -

Mark Jackman,

Chiara Marcozzi,

Martina Barbiero,

Mercedes Pardo,

Lu Yu,

Adam L. Tyson,

Jyoti S. Choudhary,

Jonathon Pines

Publication year - 2020

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.201907082

Subject(s) - microbiology and biotechnology , spindle checkpoint , kinetochore , cyclin dependent kinase 1 , g2 m dna damage checkpoint , mitosis , cyclin dependent kinase , spindle apparatus , biology , mitotic exit , cyclin b1 , cyclin b , cell cycle checkpoint , chemistry , cyclin , cell cycle , biochemistry , cell , cell division , chromosome , gene

Jackman and colleagues show that Cyclin B1-Cdk1, the major mitotic kinase, binds to the spindle checkpoint protein MAD1 and synergizes with MPS1 to facilitate MAD1 release from the nuclear pore complex and recruitment to kinetochores before nuclear envelope breakdown.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research