Relief of talin autoinhibition triggers a force-independent association with vinculin | Zendy

Paul Atherton | Zendy; Franziska Lausecker | Zendy; Alexandre F. Carisey | Zendy; Andrew Gilmore | Zendy; David R. Critchley | Zendy; Igor Barsukov | Zendy; Christoph Ballestrem | Zendy

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Relief of talin autoinhibition triggers a force-independent association with vinculin

Author(s) -

Paul Atherton,

Franziska Lausecker,

Alexandre F. Carisey,

Andrew Gilmore,

David R. Critchley,

Igor Barsukov,

Christoph Ballestrem

Publication year - 2019

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.201903134

Subject(s) - vinculin , association (psychology) , chemistry , focal adhesion , biology , microbiology and biotechnology , psychology , signal transduction , psychotherapist

Talin and vinculin control mechanosensing by linking adhesion receptors to the contractile actin cytoskeleton. Using a mitochondrial targeting system, Atherton et al. elucidate mechanisms regulating conformational changes required for vinculin binding to talin. Such activation mechanisms are not required for either protein to interact with the adhesion regulatory protein paxillin.

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