Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence | Zendy

Jacob P. Matson | Zendy; Amy M. House | Zendy; Gavin D. Grant | Zendy; Huaitong Wu | Zendy; Joanna Perez | Zendy; Jeanette Gowen Cook | Zendy

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Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence

Author(s) -

Jacob P. Matson,

Amy M. House,

Gavin D. Grant,

Huaitong Wu,

Joanna Perez,

Jeanette Gowen Cook

Publication year - 2019

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.201902143

Subject(s) - cell cycle , microbiology and biotechnology , cell cycle checkpoint , minichromosome maintenance , dna replication , g2 m dna damage checkpoint , biology , flow cytometry , cell , control of chromosome duplication , dna , genetics

Matson et al. find that human cells re-entering the cell cycle from quiescence have an impaired p53-dependent DNA replication origin licensing checkpoint and slow origin licensing. This combination makes every first S phase underlicensed and hypersensitive to replication stress.

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