DNA replication timing influences gene expression level | Zendy

Carolin A. Müller | Zendy; Conrad A. Nieduszynski | Zendy

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DNA replication timing influences gene expression level

Author(s) -

Carolin A. Müller,

Conrad A. Nieduszynski

Publication year - 2017

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.201701061

Subject(s) - replication timing , biology , genetics , dosage compensation , dna replication , gene , histone , origin recognition complex , control of chromosome duplication , eukaryotic dna replication , origin of replication , replication (statistics) , gene expression , virology

Eukaryotic genomes are replicated in a reproducible temporal order; however, the physiological significance is poorly understood. We compared replication timing in divergent yeast species and identified genomic features with conserved replication times. Histone genes were among the earliest replicating loci in all species. We specifically delayed the replication of HTA1 - HTB1 and discovered that this halved the expression of these histone genes. Finally, we showed that histone and cell cycle genes in general are exempt from Rtt109-dependent dosage compensation, suggesting the existence of pathways excluding specific loci from dosage compensation mechanisms. Thus, we have uncovered one of the first physiological requirements for regulated replication time and demonstrated a direct link between replication timing and gene expression.

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