Hedgehog signaling establishes precursors for germline stem cell niches by regulating cell adhesion | Zendy

Chun-Ming Lai | Zendy; KunYang Lin | Zendy; Shih-Han Kao | Zendy; YiNing Chen | Zendy; Fu Huang | Zendy; HweiJan Hsu | Zendy

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Hedgehog signaling establishes precursors for germline stem cell niches by regulating cell adhesion

Author(s) -

Chun-Ming Lai,

KunYang Lin,

Shih-Han Kao,

YiNing Chen,

Fu Huang,

HweiJan Hsu

Publication year - 2017

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.201610063

Subject(s) - biology , hedgehog , microbiology and biotechnology , stem cell , somatic cell , transcription factor , germline , niche , cellular differentiation , cell adhesion , drosophila melanogaster , stem cell factor , cell signaling , cell , signal transduction , genetics , progenitor cell , gene , ecology

Stem cells require different types of supporting cells, or niches, to control stem cell maintenance and differentiation. However, little is known about how those niches are formed. We report that in the development of the Drosophila melanogaster ovary, the Hedgehog (Hh) gradient sets differential cell affinity for somatic gonadal precursors to specify stromal intermingled cells, which contributes to both germline stem cell maintenance and differentiation niches in the adult. We also report that Traffic Jam (an orthologue of a large Maf transcription factor in mammals) is a novel transcriptional target of Hh signaling to control cell-cell adhesion by negative regulation of E-cadherin expression. Our results demonstrate the role of Hh signaling in niche establishment by segregating somatic cell lineages for differentiation.

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