Open AccessActive neuronal death
Author(s) -
Mitch Leslie
Publication year - 2006
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb.1724fta1
Subject(s) - nerve growth factor , biology , cycloheximide , microbiology and biotechnology , nerve cells , programmed cell death , neuroscience , biochemistry , protein biosynthesis , apoptosis , receptor
![][1] Neurons without NGF die off (top) unless cycloheximide is added (bottom).JOHNSONTake away their supply of nerve growth factor (NGF), and neurons lose the will to live. In 1988, the conventional wisdom held that the cells wasted away because NGF helped keep metabolism
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