EFFECTS OF CORTISONE ON RAT LIVER MITOCHONDRIA | Zendy

Charles U. Lowe | Zendy; Deloris MacKinney | Zendy; D. S. Sarkaria | Zendy

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EFFECTS OF CORTISONE ON RAT LIVER MITOCHONDRIA

Author(s) -

Charles U. Lowe,

Deloris MacKinney,

D. S. Sarkaria

Publication year - 1955

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.1.3.237

Subject(s) - mitochondrion , cortisone , biology , stain , cell , fixation (population genetics) , enumeration , microbiology and biotechnology , biochemistry , endocrinology , staining , genetics , mathematics , combinatorics , gene

Experiments were designed to determine the effects of parenteral administration of cortisone on mitochondrial numbers of rat liver cells. Observations were made in three ways: (1) after osmic acid fixation and appropriate stain, (2) by phase microscopy on intact cells, (3) by actual enumeration of mitochondria and nuclei to provide data on mitochondria per cell. The results of the experiments indicate that the mitochondria per cell are significantly reduced under the conditions used. Each experimental approach provided similar data, and each tended to support the results obtained from the others.

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