Effect of ritonavir and saquinavir onCandida albicansgrowth rate andin vitroactivity of aspartyl proteinases | Zendy

M. T. Blanco | Zendy; C. Hurtado | Zendy; C. PérezGiraldo | Zendy; F.J. Morán | Zendy; C. González-velasco | Zendy; A.C. Gómez-Garcı́a | Zendy

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Effect of ritonavir and saquinavir onCandida albicansgrowth rate andin vitroactivity of aspartyl proteinases

Author(s) -

M. T. Blanco,

C. Hurtado,

C. PérezGiraldo,

F.J. Morán,

C. González-velasco,

A.C. Gómez-Garcı́a

Publication year - 2003

Publication title -

medical mycology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.004

H-Index - 86

eISSN - 1460-2709

pISSN - 1369-3786

DOI - 10.1080/mmy.41.2.167.170

Subject(s) - saquinavir , candida albicans , ritonavir , in vitro , microbiology and biotechnology , chemistry , pharmacology , biology , virology , biochemistry , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy

An in vitro study to evaluate the antifungal effect and activity of aspartyl proteinases of the HIV-proteinase inhibitors ritonavir and saquinavir was conducted. Ritonavir diminished the growth rate of Candida albicans as well as the activity of its secreted aspartyl proteinases (Saps) in a nitrogen-limited medium, yeast carbon base and bovine serum albumin (YCB-BSA). This inhibition occurred in a dose-dependent fashion; with 8 mg l(-1) of ritonavir a partial growth inhibition (44%) was produced. The growth rate of C. albicans in medium with saquinavir was similar to that seen in the control, and Sap activity was inhibited only at high concentrations. In conventional medium (RPMI-1640), which does not induce the production of yeast proteases, no inhibitory effect was detected with either HIV-protease inhibitor.

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