Eumycetoma caused byCladophialophora bantianasuccessfully treated with itraconazole | Zendy

Alexandro Bonifáz | Zendy; Sybren de Hoog | Zendy; Michael R. McGinnis | Zendy; Amado Saül | Zendy; Octavio RodríguezCortés | Zendy; Javier Santibáñez | Zendy; Mariana Cruz | Zendy; Patricia Mercadillo | Zendy

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Eumycetoma caused byCladophialophora bantianasuccessfully treated with itraconazole

Author(s) -

Alexandro Bonifáz,

Sybren de Hoog,

Michael R. McGinnis,

Amado Saül,

Octavio RodríguezCortés,

Javier Santibáñez,

Mariana Cruz,

Patricia Mercadillo

Publication year - 2008

Publication title -

medical mycology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.004

H-Index - 86

eISSN - 1460-2709

pISSN - 1369-3786

DOI - 10.1080/13693780802430639

Subject(s) - itraconazole , medicine , biopsy , deformity , dorsum , fungus , dermatology , pathology , biology , antifungal , surgery , anatomy , botany

A 57-year-old male presented with dermatosis of the dorsum of the foot consisting of tumefaction, deformity and sinus tract formation. The direct examination of exudates as well as the biopsy tissue, demonstrated the presence of black granules. A dematiaceous fungus was isolated from the lesions and was identified by ribosomal DNA sequencing as Cladophialophora bantiana. This is the second report of this fungus as an etiologic agent of eumycetoma in humans. Clinical and mycologic cure was achieved after 20 months of treatment with itraconazole at a starting dose of 300 mg/day that was tapered during the course of therapy. The patient's isolate had an itraconazole MIC of 0.012 microg/ml.

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