Open AccessCentral haemodynamics in experimental acute pancreatitis
Author(s) -
Kinnala Pekka J.,
Kuttila Kari T.,
Grönroos Juha M.,
Havia Tapani V.,
Nevalainen Timo J.,
Niinikoski Juha
Publication year - 1999
Publication title -
european journal of surgery
Language(s) - English
Resource type - Journals
eISSN - 1741-9271
pISSN - 1102-4151
DOI - 10.1080/110241599750006532
Subject(s) - medicine , acute pancreatitis , pancreatitis , hemodynamics , mean arterial pressure , blood pressure , taurocholic acid , saline , anesthesia , arterial blood , central venous pressure , base excess , pancreatic duct , heart rate , bile acid
Objective: To investigate central haemodynamics in severe and mild acute pancreatitis in pigs. Design: Randomised controlled experiment. Setting: Animal laboratory, Finland. Subjects: 24 domestic pigs weighing 21–27 kg. Interventions: In 8 anaesthetised and mechanically ventilated pigs the pancreatic duct was cannulated and taurocholic acid was infused to induce severe acute pancreatitis. Eight animals received intraductal saline infusion and developed mild acute pancreatitis. Eight pigs were cannulated alone and served as controls. Main outcome measures: Cardiac index, heart rate, mean arterial pressure, central venous pressure, mean pulmonary arterial pressure, pulmonary arterial occlusion pressure, haemoglobin, arterial blood gases and acid base balance. Results: Intraductally infused taurocholic acid rapidly induced severe necrotising acute pancreatitis as assessed both macroscopically and histologically. Histological changes of mild acute pancreatitis were seen in animals after intraductal saline infusion. Central haemodynamics, arterial blood gases, and acid base balances were stable throughout the study period in all groups. The main finding was haemoconcentration as indicated by the increase in arterial haemoglobin concentration in pigs with mild and severe acute pancreatitis. Conclusion: Haemoconcentration precedes central haemodynamic alterations in experimental acute pancreatitis. Copyright © 1999 Taylor and Francis Ltd.