Open AccessComparison between plain and gentamicin containing collagen sponges in infected peritoneal cavity in rats
Author(s) -
Vaneerdeweg Wouter,
Bresseleers Tim,
Du Jardin Philippe,
Lauwers Patrick,
Pauli Steven,
Thyssens Kathia,
Van Marck Eric,
Elseviers Monique,
Eyskens Erik
Publication year - 1998
Publication title -
european journal of surgery
Language(s) - English
Resource type - Journals
eISSN - 1741-9271
pISSN - 1102-4151
DOI - 10.1080/110241598750005723
Subject(s) - gentamicin , medicine , peritoneal cavity , abdomen , caecum , surgery , abdominal cavity , sponge , peritoneum , antibiotics , microbiology and biotechnology , biology , botany
Objective: To study the usefulness of gentamicin‐containing sponges in the infected peritoneal cavity in rats. Design: Controlled study. Material: 83 Male Wistar rats, 36 of which were treated by plain sponge, 36 by gentamicin‐impregnated sponge, and 11 acted as controls. Interventions: A standard model of intraperitoneal infection was developed by making a 1 cm long incision in the caecum. Main outcome measures: Postoperative mortality, macroscopic and microscopic features of infection, and bacterial concentrations in the abdomen on days 3, 6, and 9. Results: In the respective groups 2, 3 and 2 animals died during operation and 4/34 (11%), 3/33 (9%); and 0/9 died before day 3. There were appreciable reductions in the number of animals with features of infection after 3 days but these were not significant at 6 or 9 days. Conclusion: Gentamicin‐containing collagen sponges placed on a septic focus in the abdomen reduce local infection for at least 3 days. Copyright © 1998 Taylor and Francis Ltd.