Open AccessAudit of intraoperative and early postoperative complications after introduction of mesorectal excision for rectal cancer
Author(s) -
Nesbakken Arild,
Nygaard Knut,
Westerheim Ola,
Lunde Ole Christian,
Mala Tom
Publication year - 2002
Publication title -
european journal of surgery
Language(s) - English
Resource type - Journals
eISSN - 1741-9271
pISSN - 1102-4151
DOI - 10.1080/11024150260102843
Subject(s) - medicine , total mesorectal excision , surgery , colorectal cancer , audit , cancer , general surgery , management , economics
Abstract Objective: To compare complication rates after rectal resection using a conventional surgical technique (1983–1992) and mesorectal excision (1993–2000), and to find out whether the rate of complications changed with time after the introduction of mesorectal excision. Design: Prospective, observational study. Setting: University hospital, Norway. Patients: All patients who had rectal resections for cancer in the period 1983–2000. Interventions: In the conventional surgery period 217, and in the mesorectal excision period 176, patients had rectal resections. The mesorectal excision period was split in two, the early and the late mesorectal excision period, 88 rectal resections being performed in each period. Total mesorectal excision was done in 118 patients, and partial mesorectal excision in 58. Main outcome measures: Major surgical complications in both periods; intraoperative bleeding, transfusions during the hospital stay, and cardiovascular complications in the mesorectal excision period. Results: 23/217 (11%) developed major surgical complications in the conventional surgery period, compared with 17/88 (19%) in the early mesorectal excision period ( p = 0.04). This was caused by an increased incidence of anastomotic leaks after low anterior resection, being 11/122 (9%) in the conventional surgery period and 12/52 (23%) in the early mesorectal excision period ( p = 0.01). The incidence of anastomotic leaks declined to 5/61 (8%) in the late mesorectal excision period ( p = 0.03). Multiple regression analysis identified a low anastomosis, major bleeding, and age over 75 years as significant risk factors for the development of anastomotic leaks. Major intraoperative bleeding occurred in 36/84 (43%) of the patients in the early and 22/82 (27%) in the late mesorectal period ( p = 0.04). Blood transfusions were given to 61/84 (74%) in the early mesorectal period and 41/82 (50%) in the late period ( p < 0.01). Conclusions: The incidence of surgical complications increased significantly after the introduction of mesorectal excision, but declined with time. Copyright © 2002 Taylor and Francis Ltd.