Open AccessProduction of free radicals measured by spin trapping during operations for stenosis of the carotid artery
Author(s) -
Holm Jan,
Nilsson Ulf,
Waters Nicholas,
Waters Susanna,
Jonsson Olof
Publication year - 2001
Publication title -
european journal of surgery
Language(s) - English
Resource type - Journals
eISSN - 1741-9271
pISSN - 1102-4151
DOI - 10.1080/110241501750069738
Subject(s) - medicine , stenosis , internal jugular vein , jugular vein , surgery , carotid arteries , catheter , anesthesia , cardiology
Objectives: To analyse production of free radicals during operations for stenosis of the internal carotid artery. Setting: University hospital, Sweden. Subjects: 10 patients operated on for carotid artery stenosis. Interventions: Blood samples were repeatedly drawn from the sigmoid sinus through a catheter in the internal jugular vein on the same side, before, during, and after clamping of the internal carotid artery. OXANOH was added to the blood samples in vitro and the radical production calculated from the amount oxidised to OXANO as electron spin resonance. Main outcome measures: The relation between radical production and certain clinical variables investigated by partial least squares regression analysis. Results: There were several significant relations. High systolic blood pressure and advanced age were associated with low, and severe degree of stenosis with increased, free radical production. Certain anaesthetic drugs as well as blood variables also influenced the production of radicals. Conclusions: The technique used seems to offer the possibility to find and study methods to reduce free radical production during this kind of operation. Copyright © 2001 Taylor and Francis Ltd.