Dexamethasone reduces cell surface levels of CD11b on human eosinophils | Zendy

Anuk Das | Zendy; Lina H. K. Lim | Zendy; R.J. Flower | Zendy; Mauro Perretti | Zendy

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Dexamethasone reduces cell surface levels of CD11b on human eosinophils

Author(s) -

Anuk Das,

Lina H. K. Lim,

R.J. Flower,

Mauro Perretti

Publication year - 1997

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1080/09629359791505

Subject(s) - dexamethasone , glucocorticoid , integrin alpha m , endocrinology , flow cytometry , medicine , downregulation and upregulation , stimulation , eotaxin , chemistry , hormone , incubation , inflammation , biology , immunology , chemokine , biochemistry , gene

Overnight incubation of human eosinophils (Eøs) with the glucocorticoid hormone dexamethasone (DEX; 0.1 microM) resulted in lower expression of the CD11b, but not CD49d, antigen on their plasma membrane, as assessed by flow cytometry. DEX produced a consistent inhibitory effect (ranging from 16% to 20%) when tested at a concentration of 0.1 microM. Eø stimulation with 100 ng/ml eotaxin produced an increase in CD11b (+26%), but not CD11c, levels and concomitantly a reduction (-25%) on CD62L expression. The inhibition exerted by DEX upon CD11b levels was also evident following eotaxin upregulation, with a degree of inhibition similar to that seen on basal levels. These data highlight a novel mechanism of action by which glucocorticoid hormones may be effective in reducing Eø accumulation during allergic inflammation in man.

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