In-vitro activation of complement system by lactic acidosis in newborn and adults | Zendy

Friederike Hecke | Zendy; Thomas Hoehn | Zendy; Evelyn Strauß | Zendy; Michael Obladen | Zendy; Josef Sonntag | Zendy

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In-vitro activation of complement system by lactic acidosis in newborn and adults

Author(s) -

Friederike Hecke,

Thomas Hoehn,

Evelyn Strauß,

Michael Obladen,

Josef Sonntag

Publication year - 2001

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1080/09629350123788

Subject(s) - anaphylatoxin , complement system , acidosis , lactic acidosis , lactic acid , cord blood , complement (music) , chemistry , medicine , biology , biochemistry , immunology , antibody , bacteria , complementation , gene , genetics , phenotype

Complement activation occurs secondary to a variety of external stimuli. Lactic acidosis has been previously shown to activate the complement factors C3a and C5a. In the present investigation we examined the differential effect of lactic acidosis on anaphylatoxin levels in cord and adult blood. Furthermore we aimed to determine if the entire complement cascade could be activated by lactic acidosis.

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