Administration of isoferulic acid improved the survival rate of lethal influenza virus pneumonia in mice | Zendy

Shinya Sakai | Zendy; Hiroshi Ochiai | Zendy; Naoki Mantani | Zendy; Toshiaki Kogure | Zendy; Naotoshi Shibahara | Zendy; Katsutoshi TERASAWA | Zendy

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Administration of isoferulic acid improved the survival rate of lethal influenza virus pneumonia in mice

Author(s) -

Shinya Sakai,

Hiroshi Ochiai,

Naoki Mantani,

Toshiaki Kogure,

Naotoshi Shibahara,

Katsutoshi TERASAWA

Publication year - 2001

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1080/09629350120054572

Subject(s) - pneumonia , virology , virus , medicine , microbiology and biotechnology , biology

Isoferulic acid (IFA) is a main active ingredient of the rhizoma of Cimicifuga beracleifolia, which is used frequently in Japanese traditional medicine as an anti-inflammatory drug. It has been revealed that IFA inhibits the production of macrophage inflammatory protein-2 (MIP-2), which is a murine counterpart of the chemokine family that may contribute to the pathogenesis of inflammatory diseases through the chemotactic activity for inflammatory and immune effector cells.

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