Open AccessKey Role of 12-Lipoxygenase and Its Metabolite 12-Hydroxyeicosatetraenoic Acid (12-HETE) in Diabetic Retinopathy
Author(s) -
Shuli Chen,
Haidong Zou
Publication year - 2022
Publication title -
current eye research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.836
H-Index - 81
eISSN - 1460-2202
pISSN - 0271-3683
DOI - 10.1080/02713683.2021.1995003
Subject(s) - lipoxygenase , pathogenesis , lipid signaling , hydroxyeicosatetraenoic acid , inflammation , reactive oxygen species , diabetic retinopathy , arachidonate 5 lipoxygenase , biology , microbiology and biotechnology , nadph oxidase , arachidonic acid , biochemistry , chemistry , endocrinology , immunology , enzyme , diabetes mellitus
Abnormal lipid metabolism has been proved to be implicated in the complex pathogenesis of diabetic retinopathy (DR). 12-lipoxygenase (12-LOX) is a member of lipoxygenase family responsible for the oxygenation of cellular polyunsaturated fatty acids to produce lipid mediators which modulate cell inflammation. This review explores the role of 12-lipoxygenase and its products in the pathogenesis of DR.