Open AccessRenal Papillary Necrosis
Author(s) -
Amy E. Brix
Publication year - 2002
Publication title -
toxicologic pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.613
H-Index - 108
eISSN - 1533-1601
pISSN - 0192-6233
DOI - 10.1080/01926230290166760
Subject(s) - renal papillary necrosis , necrosis , renal papilla , medicine , pathology , kidney , urology
Renal papillary necrosis (RPN) is a signifi cant problem in human beings, especially in England and in Australia where it has been reported to account for 15% to 20% of patients needing renal transplants. Many compounds, including aspirin, phenacetin, phenylbutazone , indomethacin, mefenamic acid, flufenamic acid, fenoprofin, naproxen, and ibuprofen have been linked to renal papillary necrosis in human beings. Although the exact mechanism of RPN is unknown, there are several theories that have good scientifi c evidence behind them. Study of RPN in animals as models for the disease in human beings is limited by several factors, including anatomical differences between human beings and most animal species as well as technical diffi culties in studying the renal papilla.