A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22 | Zendy

John R. Kelsoe | Zendy; M. Anne Spence | Zendy; Erika Loetscher | Zendy; M. Foguet | Zendy; A. Dessa Sadovnick | Zendy; Ronald A. Remick | Zendy; Pamela Flodman | Zendy; Jason V. Khristich | Zendy; Zofi MroczkowskiParker | Zendy; John Brown | Zendy; Diane Masser | Zendy; Sharon Ungerleider | Zendy; Mark Hyman Rapaport | Zendy; William Wishart | Zendy; H. Luebbert | Zendy

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A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22

Author(s) -

John R. Kelsoe,

M. Anne Spence,

Erika Loetscher,

M. Foguet,

A. Dessa Sadovnick,

Ronald A. Remick,

Pamela Flodman,

Jason V. Khristich,

Zofi MroczkowskiParker,

John Brown,

Diane Masser,

Sharon Ungerleider,

Mark Hyman Rapaport,

William Wishart,

H. Luebbert

Publication year - 2001

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.98.2.585

Subject(s) - bipolar disorder , irritability , locus (genetics) , centimorgan , genetics , psychiatry , mania , twin study , population , mood , psychology , medicine , biology , anxiety , gene mapping , chromosome , gene , heritability , environmental health

Bipolar disorder or manic depressive illness is a major psychiatric disorder that is characterized by fluctuation between two abnormal mood states. Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy. The etiology is currently unknown; however, numerous family, twin, and adoption studies have argued for a substantial genetic contribution. We have conducted a genome survey of bipolar disorder using 443 microsatellite markers in a set of 20 families from the general North American population to identify possible susceptibility loci. A maximum logarithm of odds score of 3.8 was obtained at D22S278 on 22q. Positive scores were found spanning a region of nearly 32 centimorgans (cM) on 22q, with a possible secondary peak at D22S419. Six other chromosomal regions yielded suggestive evidence for linkage: 3p21, 3q27, 5p15, 10q, 13q31-q34, and 21q22. The regions on 22q, 13q, and 10q have been implicated in studies of schizophrenia, suggesting the possible presence of susceptibility genes common to both disorders.

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