Open AccessSEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans
Author(s) -
Timothy G. Doyle,
Chenhui Wen,
Iva Greenwald
Publication year - 2000
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.97.14.7877
Subject(s) - caenorhabditis elegans , transcription factor , microbiology and biotechnology , biology , coactivator , nuclear receptor , signal transduction , notch signaling pathway , intracellular , gene , genetics
LIN-12 and GLP-1 are members of the LIN-12/Notch family of receptors that mediate cell–cell interactions during development. Thesel-8 gene had been identified previously in a screen for suppressors of a mutation that constitutively activates LIN-12. Here, we report thatsel-8 is essential forlin-12- andglp-1- mediated signaling, and that SEL-8 is a glutamine-rich nuclear protein. We postulate that SEL-8 serves as a transcriptional coactivator or as an assembly factor for transcription complexes that contain the LIN-12 or GLP-1 intracellular domains.