SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans | Zendy

Timothy G. Doyle | Zendy; Chenhui Wen | Zendy; Iva Greenwald | Zendy

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SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans

Author(s) -

Timothy G. Doyle,

Chenhui Wen,

Iva Greenwald

Publication year - 2000

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.97.14.7877

Subject(s) - caenorhabditis elegans , transcription factor , microbiology and biotechnology , biology , coactivator , nuclear receptor , signal transduction , notch signaling pathway , intracellular , gene , genetics

LIN-12 and GLP-1 are members of the LIN-12/Notch family of receptors that mediate cell–cell interactions during development. Thesel-8 gene had been identified previously in a screen for suppressors of a mutation that constitutively activates LIN-12. Here, we report thatsel-8 is essential forlin-12- andglp-1- mediated signaling, and that SEL-8 is a glutamine-rich nuclear protein. We postulate that SEL-8 serves as a transcriptional coactivator or as an assembly factor for transcription complexes that contain the LIN-12 or GLP-1 intracellular domains.

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