The dimensions of the protein import channels in the outer and inner mitochondrial membranes | Zendy

Michael P. Schwartz | Zendy; Andreas Matouschek | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The dimensions of the protein import channels in the outer and inner mitochondrial membranes

Author(s) -

Michael P. Schwartz,

Andreas Matouschek

Publication year - 1999

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.96.23.13086

Subject(s) - translocase of the inner membrane , inner membrane , translocase of the outer membrane , inner mitochondrial membrane , membrane , bacterial outer membrane , biophysics , mitochondrial carrier , transmembrane protein , mitochondrial membrane transport protein , mitochondrion , chemistry , membrane protein , microbiology and biotechnology , biology , biochemistry , receptor , escherichia coli , gene

Most mitochondrial proteins are imported into mitochondria through transmembrane channels composed largely, and perhaps exclusively, of proteins. We have determined the effective internal diameter of the protein import channel in the mitochondrial outer membrane to be between 20 A and 26 A during translocation. The diameter of the import channel in the inner membrane is smaller than the diameter of the outer membrane import channel. These results were obtained by measuring the effect of rigid steric bulk introduced into precursor proteins on import.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research