Open AccessA systematic study of low-resolution recognition in protein–protein complexes
Author(s) -
Ilya A. Vakser,
Omar G. Matar,
Chan F. Lam
Publication year - 1999
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.96.15.8477
Subject(s) - dock , docking (animal) , low resolution , resolution (logic) , computer science , molecular recognition , pattern recognition (psychology) , artificial intelligence , high resolution , chemistry , biochemistry , geography , molecule , medicine , remote sensing , nursing , organic chemistry
A comprehensive nonredundant database of 475 cocrystallized protein–protein complexes was used to study low-resolution recognition, which was reported in earlier docking experiments with a small number of proteins. The docking programgramm was used to delete the atom-size structural details and systematically dock the resulting molecular images. The results reveal the existence of the low-resolution recognition in 52% of all complexes in the database and in 76% of the 113 complexes with an interface area >4,000 Å2 . Limitations of the docking and analysis tools used in this study suggest that the actual number of complexes with the low-resolution recognition is higher. However, the results already prove the existence of the low-resolution recognition on a broad scale.