The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae | Zendy

Catherine Berset | Zendy; Hans Trachsel | Zendy; Michael Altmann | Zendy

Open Access

The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae

Author(s) -

Catherine Berset,

Hans Trachsel,

Michael Altmann

Publication year - 1998

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.95.8.4264

Subject(s) - eif4g , eif4e , initiation factor , saccharomyces cerevisiae , eukaryotic initiation factor , biology , eukaryotic translation initiation factor 4 gamma , eukaryotic translation , microbiology and biotechnology , signal transduction , translation (biology) , eif4a1 , protein biosynthesis , eif4ebp1 , messenger rna , biochemistry , yeast , gene

Initiation factor eIF4G is an essential protein required for initiation of mRNA translation via the 5′ cap-dependent pathway. It interacts with eIF4E (the mRNA 5′ cap-binding protein) and serves as an anchor for the assembly of further initiation factors. With treatment ofSaccharomyces cerevisiae with rapamycin or with entry of cells into the diauxic phase, eIF4G is rapidly degraded, whereas initiation factors eIF4E and eIF4A remain stable. We propose that nutritional deprivation or interruption of the TOR signal transduction pathway induces eIF4G degradation.

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