KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion | Zendy

Kyungjae Myung | Zendy; Corey Braastad | Zendy; Dong Ming He | Zendy; Eric A. Hendrickson | Zendy

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KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion

Author(s) -

Kyungjae Myung,

Corey Braastad,

Dong Ming He,

Eric A. Hendrickson

Publication year - 1998

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.95.13.7664

Subject(s) - ataxia telangiectasia , biology , dna , gene , microbiology and biotechnology , locus (genetics) , dna repair , dna damage , genetics

The KARP-1 (Ku86 Autoantigen Related Protein-1) gene, which is expressed from the human Ku86 autoantigen locus, appears to play a role in mammalian DNA double-strand break repair as a regulator of the DNA-dependent protein kinase complex. Here we demonstrate that KARP-1 gene expression is significantly up-regulated following exposure of cells to DNA damage. KARP-1 mRNA induction was completely dependent on the ataxia telangiectasia and p53 gene products, consistent with the presence of a p53 binding site within the second intron of the KARP-1 locus. These observations link ataxia telangiectasia, p53, and KARP-1 in a common pathway.

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