Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10 | Zendy

Beat M. Riederer | Zendy; Véronique PellierMonnin | Zendy; Bruno Antonsson | Zendy; Gilbert Di Paolo | Zendy; Stephen A. Stimpson | Zendy; Robert Lütjens | Zendy; Stefan Catsicas | Zendy; Gabriele Grenningloh | Zendy

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Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10

Author(s) -

Beat M. Riederer,

Véronique PellierMonnin,

Bruno Antonsson,

Gilbert Di Paolo,

Stephen A. Stimpson,

Robert Lütjens,

Stefan Catsicas,

Gabriele Grenningloh

Publication year - 1997

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.94.2.741

Subject(s) - neurite , microtubule , microbiology and biotechnology , biology , growth cone , intracellular , microtubule associated protein , regulator , neuron , transfection , cell culture , axon , neuroscience , in vitro , genetics , gene

Dynamic assembly and disassembly of microtubules is essential for cell division, cell movements, and intracellular transport. In the developing nervous system, microtubule dynamics play a fundamental role during neurite outgrowth, elongation, and branching, but the molecular mechanisms involved are unknown. SCG10 is a neuron-specific protein that is membrane-associated and highly enriched in growth cones. Here we show that SCG10 binds to microtubules, inhibits their assembly, and can induce microtubule disassembly. We also show that SCG10 overexpression enhances neurite outgrowth in a stably transfected neuronal cell line. These data identify SCG10 as a key regulator of neurite extension through regulation of microtubule instability.

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